CV

A pdf version of my CV is available on the right.

General Information

Full Name Zehua Wang (Zack Wang)
Date of Birth 23rd May 2000
Languages English, Chinese, Cantonese, Japanese

Education

  • Expected 2025
    Master’s Degree in Pharmacokinetics
    China Pharmaceutical University, Nanjing, China
    • GPA: 3.8/4.0
    • IELTS: 6.5, CET-6: 567
    • Main research experience 1: ADC Drug Modeling and Analysis: Led the development of whole-body PBPK, semi-PBPK, and PD models for Antibody-Drug Conjugates (ADCs), identifying key factors influencing pharmacokinetics, pharmacodynamics, and toxicity. Conducted virtual population-based clinical trials, focusing on sensitivity analysis, optimizing dosing strategies, and mitigating clinical toxicities. Software: Monolix, Phoenix Winnonlin, Berkeley Madonna, PK-Sim, R.
    • Main research experience 2: Alzheimer’s Antibody Therapy Pop-PKPD Models: Spearheaded the development of population PKPD models, incorporating disease progression models for Alzheimer's disease patients. Analyzed the relationship between drug exposure and biomarkers to optimize personalized treatments.
    • Main research experience 3: Drug Metabolism and Transport Mechanisms: Investigated interactions between transporters and metabolic enzymes under pathological conditions affecting the CNS, integrating molecular biology techniques with advanced data analysis.
    • Main research experience 4: Phase I NSAID Clinical Pharmacometrics Study: In collaboration with industry, led a pharmacometrics study on novel NSAIDs, overseeing data modeling, parameter estimation, physicochemical property characterization, and optimization of therapeutic regimens.
  • 2022
    Bachelor of Engineering in Pharmaceutical Engineering
    Shandong First Medical University, Jinan, China
    • Average Score: 83.5/100
    • CET-4: 592
    • Main research experience: Prepared various MOF-derived carbon materials for water purification tests and compared their performance under different conditions.

Honors and Awards

  • 2024
    • Exploring the World Scholarship, CPU
  • 2022-2024
    • Outstanding League Member, CPU
    • Scholarship of Academic Excellence, CPU
  • 2022
    • Outstanding Graduate, SDFMU
  • 2019-2021
    • Prize Scholarship, SDFMU

Academic Interests

  • Pharmacometrics
    • PK-PD (pharmacokinetics and pharmacodynamics) and Population Modeling: Optimizes drug design, predicts efficacy and safety, and addresses target-mediated drug disposition. Population PK/PD helps assess patient variability and supports cross-species scaling for clinical trials and precision medicine.
    • QSP (Quantitative Systems Pharmacology): Integrates mechanistic models with PK/PD data to guide drug development, optimize dosing, and enhance understanding of complex biological systems.
    • Immunogenicity: Addresses immune responses and nonlinear kinetics in large molecule drugs, ensuring therapeutic outcomes in clinical and industrial applications.
    • Regulatory and Clinical Exemptions: Supports regulatory submissions and potentially streamlines clinical trials with trial exemptions, accelerating drug development and approval.
    • Web-based Models: Used for simulating drug behavior, visualizing results, and facilitating real-time decision-making in collaboration with clinicians and regulators.
  • Pharmacology and Pathology
    • Drug Transport and BBB Interaction: Investigated transporters' roles (e.g., OCTs, MATE1) in drug disposition across the blood-brain barrier, focusing on how peripheral diseases like liver pathology affect CNS drug exposure.
    • CNS Pharmacokinetics and Drug Metabolism: Explored CNS drug distribution and efficacy in the context of metabolic changes in peripheral organs.
    • Peripheral Organ Pathology and CNS Dysfunction: Examined the impact of peripheral diseases, like liver injury, on CNS drug metabolism using in vivo and in vitro models.
    • Neuroprotective Drug Development: Researched the development of drugs aimed at protecting CNS function, particularly in cases where peripheral pathology leads to secondary CNS damage.
    • Cancer Therapy with Large Molecule Drugs: Focused on developing and optimizing Antibody-Drug Conjugates (ADCs) for the treatment of cancers such as breast and gastric cancer, with an emphasis on PK-PD and clinical outcomes.
    • Drug Addiction and Withdrawal Treatment.

Other Interests

  • Photography and Filmmaking: Experienced in photography and micro-movie production, having received multiple provincial and school-level awards. Skilled in new media management and content creation.
  • Chess: Over 10 years of competitive chess experience, with a history of winning various provincial chess competitions.
  • Sports: Proficient in swimming, table tennis, and badminton, with a focus on maintaining a healthy balance between academics and physical activities.