I am Zack (Zehua) Wang, a PhD candidate in Pharmacology and Clinical Pharmacology at the University of Auckland. I specialise in pharmacometrics, population pharmacokinetic and pharmacodynamic modelling, clinical trial simulation, disease progression modelling, and model-informed dosing.
My research uses nonlinear mixed-effects models and simulation to support dose selection and to quantify treatment effects and disease progression. Current work includes vancomycin area under the concentration-time curve (AUC)-guided dosing and Bayesian dose prediction in infectious diseases, disease progression modelling in Alzheimer’s disease, and physiologically based pharmacokinetic and pharmacodynamic modelling of antibody-drug conjugates.
I use NONMEM, R, Phoenix WinNonlin, and Python, and have contributed pharmacometric analyses to industry-sponsored phase I and II clinical trials. I am interested in opportunities in pharmacometrics, clinical pharmacology, regulatory science, and model-informed drug development across pharmaceutical companies, biotechnology organisations, and contract research organisations.