Zack Wang

Doctoral Candidate
School of Medicine, University of Auckland

Auckland, New Zealand

I am Zehua (Zack) Wang, a doctoral candidate in Pharmacology and Clinical Pharmacology at the University of Auckland’s School of Medicine. My work is centred on a practical question: what evidence is needed for model-informed dosing to be useful in routine clinical care?

My doctoral research, Advancing the Evidence for Model-Based Dosing in the Clinical Setting, evaluates dosing and sampling decisions for high-risk medicines through clinical trial simulation, population pharmacokinetic/pharmacodynamic modelling, optimal design, and retrospective assessment of existing model-based dosing frameworks. I aim to make quantitative evidence clear enough for clinicians, pharmacometricians, and health-system decision makers to use and challenge.

Before Auckland, I completed an M.Sc. at China Pharmaceutical University and a B.Eng. at Shandong First Medical University. My earlier work focused on translational PBPK/PD and drug-disposition modelling, including topoisomerase inhibitor antibody-drug conjugates, SPT-07A, transporter-mediated effects of liver injury, and metformin exposure in acute liver injury.

I like work that is quantitative without becoming opaque: reproducible code, explicit assumptions, careful model diagnostics, and results that can be read by people outside the modelling room. I am especially interested in clinical trial simulation, model-informed dosing, antimicrobial dosing, optimal sampling, and implementation evidence for pharmacometrics in healthcare.

selected publications

EJPS

PBPK-PD model for predicting pharmacokinetics, tumor growth inhibition, and toxicity risks of topoisomerase inhibitor ADCs in mice and humans

Zehua Wang, Jinwei Zhu, Lan Sang, Linxiu Tang, Sasa Zhang, Yongmei Tan, and 2 more authors

European Journal of Pharmaceutical Sciences, 2025

Bib HTML

@article{wang2025pbpkpd,
  title = {PBPK-PD model for predicting pharmacokinetics, tumor growth inhibition, and toxicity risks of topoisomerase inhibitor ADCs in mice and humans},
  author = {Wang, Zehua and Zhu, Jinwei and Sang, Lan and Tang, Linxiu and Zhang, Sasa and Tan, Yongmei and Zhao, Yanlin and Hao, Kun},
  journal = {European Journal of Pharmaceutical Sciences},
  volume = {213},
  pages = {107234},
  year = {2025},
  doi = {10.1016/j.ejps.2025.107234},
}

Pharmaceutics

Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data

Xiaoqiang Zhu, Weimin Kong, Zehua Wang, Xiaodong Liu, and Li Liu

Pharmaceutics, 2024

Bib HTML

@article{zhu2024spt07a,
  title = {Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data},
  author = {Zhu, Xiaoqiang and Kong, Weimin and Wang, Zehua and Liu, Xiaodong and Liu, Li},
  journal = {Pharmaceutics},
  volume = {16},
  number = {12},
  pages = {1596},
  year = {2024},
  doi = {10.3390/pharmaceutics16121596},
}

DMD

Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of organic cation transporters OCT1/2 and OCTN2 at the blood-brain barrier

Hao Zhi, Zhongyan Wang, Xinyue Zhu, Wenhan Wu, Lu Yang, Yidong Dai, and 5 more authors

Drug Metabolism and Disposition, 2025

Bib HTML

@article{zhi2025carnitine,
  title = {Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of organic cation transporters OCT1/2 and OCTN2 at the blood-brain barrier},
  author = {Zhi, Hao and Wang, Zhongyan and Zhu, Xinyue and Wu, Wenhan and Yang, Lu and Dai, Yidong and Wang, Zehua and Jiang, Ling and Shao, Haoran and Liu, Xiaodong and Liu, Li},
  journal = {Drug Metabolism and Disposition},
  volume = {53},
  number = {5},
  pages = {100072},
  year = {2025},
  doi = {10.1016/j.dmd.2025.100072},
}

Biomedicines

Thioacetamide-Induced Acute Liver Injury Increases Metformin Plasma Exposure by Downregulating Renal OCT2 and MATE1 Expression and Function

Hao Zhi, Yidong Dai, Lin Su, Lu Yang, Wenhan Wu, Zehua Wang, and 2 more authors

Biomedicines, 2023

Bib HTML

@article{zhi2023metformin,
  title = {Thioacetamide-Induced Acute Liver Injury Increases Metformin Plasma Exposure by Downregulating Renal OCT2 and MATE1 Expression and Function},
  author = {Zhi, Hao and Dai, Yidong and Su, Lin and Yang, Lu and Wu, Wenhan and Wang, Zehua and Zhu, Xinyue and Liu, Li},
  journal = {Biomedicines},
  volume = {11},
  number = {12},
  pages = {3314},
  year = {2023},
  doi = {10.3390/biomedicines11123314},
}