Publications

2025

1. EJPS

   PBPK-PD model for predicting pharmacokinetics, tumor growth inhibition, and toxicity risks of topoisomerase inhibitor ADCs in mice and humans

   Zehua Wang, Jinwei Zhu, Lan Sang, Linxiu Tang, Sasa Zhang, Yongmei Tan, and 2 more authors

   European Journal of Pharmaceutical Sciences, 2025

   Bib HTML

   @article{wang2025pbpkpd,
     title = {PBPK-PD model for predicting pharmacokinetics, tumor growth inhibition, and toxicity risks of topoisomerase inhibitor ADCs in mice and humans},
     author = {Wang, Zehua and Zhu, Jinwei and Sang, Lan and Tang, Linxiu and Zhang, Sasa and Tan, Yongmei and Zhao, Yanlin and Hao, Kun},
     journal = {European Journal of Pharmaceutical Sciences},
     volume = {213},
     pages = {107234},
     year = {2025},
     doi = {10.1016/j.ejps.2025.107234},
   }

2. DMD

   Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of organic cation transporters OCT1/2 and OCTN2 at the blood-brain barrier

   Hao Zhi, Zhongyan Wang, Xinyue Zhu, Wenhan Wu, Lu Yang, Yidong Dai, and 5 more authors

   Drug Metabolism and Disposition, 2025

   Bib HTML

   @article{zhi2025carnitine,
     title = {Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of organic cation transporters OCT1/2 and OCTN2 at the blood-brain barrier},
     author = {Zhi, Hao and Wang, Zhongyan and Zhu, Xinyue and Wu, Wenhan and Yang, Lu and Dai, Yidong and Wang, Zehua and Jiang, Ling and Shao, Haoran and Liu, Xiaodong and Liu, Li},
     journal = {Drug Metabolism and Disposition},
     volume = {53},
     number = {5},
     pages = {100072},
     year = {2025},
     doi = {10.1016/j.dmd.2025.100072},
   }

2024

1. Pharmaceutics

   Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data

   Xiaoqiang Zhu, Weimin Kong, Zehua Wang, Xiaodong Liu, and Li Liu

   Pharmaceutics, 2024

   Bib HTML

   @article{zhu2024spt07a,
     title = {Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data},
     author = {Zhu, Xiaoqiang and Kong, Weimin and Wang, Zehua and Liu, Xiaodong and Liu, Li},
     journal = {Pharmaceutics},
     volume = {16},
     number = {12},
     pages = {1596},
     year = {2024},
     doi = {10.3390/pharmaceutics16121596},
   }

2023

1. Biomedicines

   Thioacetamide-Induced Acute Liver Injury Increases Metformin Plasma Exposure by Downregulating Renal OCT2 and MATE1 Expression and Function

   Hao Zhi, Yidong Dai, Lin Su, Lu Yang, Wenhan Wu, Zehua Wang, and 2 more authors

   Biomedicines, 2023

   Bib HTML

   @article{zhi2023metformin,
     title = {Thioacetamide-Induced Acute Liver Injury Increases Metformin Plasma Exposure by Downregulating Renal OCT2 and MATE1 Expression and Function},
     author = {Zhi, Hao and Dai, Yidong and Su, Lin and Yang, Lu and Wu, Wenhan and Wang, Zehua and Zhu, Xinyue and Liu, Li},
     journal = {Biomedicines},
     volume = {11},
     number = {12},
     pages = {3314},
     year = {2023},
     doi = {10.3390/biomedicines11123314},
   }